Lion Larry Leguire Ph.D., MBA has retired as Scientific Advisor of the Ohio LIONS Eye Research Foundation (OLERF) effective Dec. 1, 2011.  Dr. Leguire served as Scientific Advisor of the OLERF since 1996.  In the year 2000, he established and served as the Web Master of the

UNIVERSITY of CINCINNATI DEPARTMENT OF OPHTHALMOLOGY by: Winston  Kao, Ph.D. PROGRESS REPORT Significance Corneal transplantation, i.e., penetrating and lamellar keratoplasty, is the most effective treatment of corneal blindness caused by congenital gene mutation and trauma.

Investigator: Andrew Hartwick, OD PhD; College of Optometry, Ohio State University Introduction: There is now considerable evidence that three types of photoreceptors (rods, cones and intrinsically photosensitive retinal ganglion cells [ipRGCs]) contribute photic information to

CASE WESTERN RESERVE UNIVERSITY DEPARTMENT OF OPHTHALMOLOGY AND VISUAL SCIENCES OHIO LIONS EYE RESEARCH FOUNDATION Continuation Grant Application, 2011 Jonathan H. Lass, M.D., Charles I Thomas Professor and Chairman Eric Pearlman, Ph.D., Professor and Director of Research

Intravitreal anti-VEGF agents such as avastin, lucentis and macugen with wet macular degeneration.  (Christoforidis) The project of radiolabeling of anti-VEGF agents was actively continued these past 12 months. The results of the work have received national and international

NATIONWIDE CHILDREN’S HOSPITAL DEPARTMENT OF OPHTHALMOLOGY PROGRESS REPORT In 2010-2011 research efforts continued to concentrate on identifying sites within the brain responsible for the abnormal eye movements in patients with infantile nystagmus syndrome. Dr. Kashou in

By L. E. Leguire Ph.D., MBA “What do you mean she has lazy eye in both eyes!” exclaimed Judy’s mother. Shocked, she sat in disbelief as the eye doctor explained the results of Judy’s comprehensive eye exam. “Isn’t lazy eye a problem with one eye and

The Influence of Biomechanical Ocular Properties and Ocular Pulse Amplitude in Glaucoma.  (Roberts, Weber, Fleming, and Sawchyn) Work will continue on the hypothesis proposed previously, describing the influence of the variation in intraocular pressure caused by the heart beat

WRIGHT STATE UNIVERSITY Daniel T. Organisciak Ph.D. Progress Report OLERF Report, July 1, 2010 – July 1, 2011 The rate of vision loss in age-related macular degeneration (AMD) and in retinitis pigmentosa (RP) exceeds the modest rate of visual cell loss in people unaffected

The Investigation of Multifunctional Microbubbles for Sustained Release in Intravitreal Injection of anti-VEGF agents.  (Xu, Letson, Roberts) The goal of this ongoing project is to investigate novel methods of encapsulation of anti-VEGF agents in the fabrication of microbubbles